Science Inventory

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Per- and polyfluoroalkyl substances (PFAS) are compounds found in many consumer and industrial products with ubiquitous spread in environmental matrices. While there is evidence that some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), cause d...

Anxiety may be related to chemical exposure during brain development, so there’s a need to assess anxiety after exposure to environmental chemicals. However, there is not a standard high throughput assay to assess mental health effects of exposure. There is a promising test...

Wetland restoration and construction are important land management options for retaining nitrogen and phosphorus and thereby improving water quality at local scales (i.e., at nearby streams). However, limited information exists regarding the cumulative influence of wetlands outsi...

Agricultural best management practices/conservation practices (ag BMPs/ACPs) have been widely implemented for nonpoint source pollution control. However, through a Region 10 R2P2 project, we have identified two critical knowledge gaps that limit broader adoption of ACPs in the Pa...

Over the last 10 years the EPA has been conducting research to better quantify the magnitude of greenhouse gas emissions from US reservoirs.   In 2021 reservoirs were included in the Inventory of US Greenhouse Gas Emissions and Sinks for the first time and currently estimate...

To continue estimating hedonic property models, possibly expanding environmental justice analyses, and undertaking other analyses that use property characteristics, EPA is interested in acquiring national property transaction data as a replacement for Zillow’s ZTRAX data. Z...

New approach methodologies (NAMs) are being evaluated for their utility to inform developmental neurotoxicity (DNT) hazard instead of using animals. This work compares predictive models for DNT using DNT NAMs data. The dataset comprised 200 chemicals screened in 17 DNT assays wit...

This is a public presentation on the potential effects of nutrients in smoke on downwind cyanobacteria blooms. Wildfire activity is increasing in the continental U.S. and can be linked to climate change effects, including rising temperatures and more frequent drought conditions. ...

The relationship between environmental chemical exposure and a spectrum of neurological diseases is well-established. However, unraveling the underlying mechanism between human exposure and toxic outcomes presents significant challenges. Evaluation of neurotoxicity potential usin...

The meeting aims to 1) discuss progress towards updating the Initial Recommendations to an OECD guidance, 2) discuss the regulatory implementation of the current DNT-IVB and strategy to include/exclude additional assays, and 3) discuss complementary aspects of the guidance that a...

Neurite outgrowth is an important precursor to synapse formation and assays for neurite outgrowth are part of an in vitro battery (IVB) of assays for developmental neurotoxicity screening (DNT). This battery of assays evaluates chemical effects on key neurodevelopmental processes...

Background and Purpose: Current in vitro toxicology methods typically rely on exposure of cells to compounds that were added to the culture media. For neurotoxicity, in vitro exposure of rat cortical neural networks plated on multi-well microelectrode array plates (MEAs) have bee...

EPA has conducted prior decontamination research for traditional CWAs, but there is a scientific data gap for decontamination technologies capable of remediating sensitive equipment contaminated with a Fourth Generation Agent (FGA). The purpose of this project was to evaluate the...

Background: In vitro new approach methods (NAMs) have been developed for evaluating developmental neurotoxicity (DNT) potential. One such DNT NAM, the Network Formation Assay (NFA), uses a twelve-day exposure model to measure neuronal network activity changes in primary rat corti...

This is an invited outreach presentation to provide an introduction to environmental justice. It presents no new data or ongoing research from ORD.

This presentation seeks to provide basic information about PFAS chemistry, occurrence, and accumulation/potential impacts in biota to a group of non-scientists. This presentation includes no EPA data. 

Arsenic discharge and mobilization from the pollution source depend on the minerals that host arsenic, the matrix of local water, the redox condition, and the water flow. A disposable enzyme sensor has been developed for As(III) determination in site assessment. To evaluate the s...

Over the past decade, a concerted effort has been made to develop in vitro and alternative assays that detect compounds with the potential to cause developmental neurotoxicity. As a result, a battery of assays has been developed that is believed to be useful for decision-making r...

While SWMM has arguably played a pivotal role in pollution control in collection systems since its introduction, traditional applications using the model have been relatively static. They typically involve calibrating and validating SWMM models with data collected and curated for...

Protein processing operations include animal slaughtering, meat and poultry product production, and/or rendering of byproducts. These facilities utilize large volumes of water for hair/hide/feather removal, carcass washing, chilling, trimming and cutting, cooking, and cleaning/sa...

Assessing the fate of PFAS in the environment requires improved analytical methodologies to quantify a greater variety of PFAS and application of these methods to investigate their occurrence in complex sample matrices. PFAS precursors are a compound class of emerging concern tha...

This presentation will cover the exposure pathways of PFAS with particular emphasis on biosolids and landfills.   Temporal and Spatial Assessment of PFAS in Wastewater Treatment- Project designed to:  Develop a better understanding of the temporal variability of PF...

This presentation provides an overview of EPA Office of Research Development's extramural research grant programs that are managed by the Office of Science Advisor, Policy and Engagement

This is the PowerPoint slide deck for the Science to Achieve Results (STAR) “Air Quality Information: Making Sense of Air Pollution Data to Inform Decisions in Underserved Communities Overburdened by Air Pollution” Funding Opportunity Informational Webinar that will b...

Bacillus anthracis, the causative agent of inhalation anthrax, is one of the most highly studied biological threat agents. Significant gaps remain related to the remediation of a wide area following such biological release. This extends to the remediation of critical assets owned...